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FRTR Presenter: some tweaks on pfas along the way. Risk assessment basics for human health. And it's Linda Grimes

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FRTR Presenter: from EPA, who will be our speaker.

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FRTR Presenter: And here's the little bio. It's an environmental engineer, environmental health scientist worked on site assessments, water wastewater work, air permits hazardous waste permits

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FRTR Presenter: PE license. Phd, focused on environmental health. She doesn't tell me where she went to school. I can't remember.

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FRTR Presenter: Yeah, don't we all

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FRTR Presenter: so she's the master of the regional screening levels. And I didn't know that until what I read this. So all right, there you go.

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FRTR Presenter: Yeah, it's funny. Most people used to know me for the ourselves. Now it's pfas. So there you go! So I'm in the inevitable position of keeping you from lunch, so I hope to get you to lunch on time, if not early.

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FRTR Presenter: Okay? So I was asked to give you some basics on risk assessment. I'm going to mainly be giving you a super fund perspective. But I will be discussing a little bit of some another program.

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FRTR Presenter: but in general, with risk assessment.

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FRTR Presenter: So well in superfund. First, st there's the planning, the scoping. You need to gather actual data before you can do a risk assessment.

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FRTR Presenter: And risk is a combination of toxicity and of exposure.

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FRTR Presenter: You can have toxicity, but if there's no exposure, there's not a risk

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FRTR Presenter: in superfund, we don't normally do the toxicity assessments, although sometimes there might be a site specific need exposure. Assessment is always going to be site specific in superfund.

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FRTR Presenter: and then you combine those. And now you get the risk.

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FRTR Presenter: So a toxicity assessment is an investigation into how toxic a contaminant may be to human health

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FRTR Presenter: or the hazard identification, the dose response relationship. I should note, I'm only going to be discussing human health. I don't do eco risk.

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FRTR Presenter: So with toxicity assessments. It's discussing what kind of harm are you going to be dealing with what illness or health effect may occur, and how much exposure can cause harm?

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FRTR Presenter: Maybe I should also mention within superfund. We hope to to stop the risk before you get to one of those.

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FRTR Presenter: There's really bad endpoints like death. So we're we're looking more of what are those long-term health effects?

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FRTR Presenter: So within toxicity we consider there to be 2 different categories of toxicity. There's non-carcinogenic chemicals. They are believed to act via threshold mechanism of action, which means that there's a level of exposure below which it's unlikely for an effect to occur.

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FRTR Presenter: And then there's carcinogenic chemicals. They're believed to act via non-threshold mechanism of action. But a risk may be the risk may be associated with any exposure level.

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FRTR Presenter: Of course I should also note many chemicals can cause both a carcinogenic effect and a non-carcinogenic effect. So we have to consider both.

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FRTR Presenter: Now with an exposure assessment

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FRTR Presenter: you are. You're looking at what are your exposure? Pathways and the main expo? The way we look at exposure is inhalation. Are you breathing something in? And it doesn't have to be necessarily volatile. It can be like an aerosol

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FRTR Presenter: oral. How somebody, you know you're eating it.

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FRTR Presenter: or dormal, you can come in contact with water or soil.

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FRTR Presenter: etc.

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FRTR Presenter: We consider the exposure duration. There's acute exposure. And so that's very short term.

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FRTR Presenter: There's

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FRTR Presenter: well acute is like kind of right away right short term longer term chronic and I will note there are different definitions of what these time spans are.

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FRTR Presenter: For example, atsdr and EPA consider chronic. There we look at them a little bit differently, but long term.

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FRTR Presenter: Now with the potential exposed population again within superfund, this is definitely going to be site specific.

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FRTR Presenter: So, for example,

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FRTR Presenter: if you're looking at an industrial area, you're going to be considering workers. And hopefully, those workers will all be adults.

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FRTR Presenter: Whereas residential you're going to be considering, you know more children, the elderly you might be considering pregnant women. What are those?

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FRTR Presenter: What are your more?

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FRTR Presenter: In other words, we want to look at everyone but someone. Some of them are more at risk.

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FRTR Presenter: An exposure is quantified as the amount of the agent available at the exchange boundaries.

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FRTR Presenter: How much are you ingesting? How much are you breathing in?

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FRTR Presenter: And also again going back to who is being exposed.

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FRTR Presenter: and how much of the contaminants are they being exposed to?

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FRTR Presenter: So again, with the I probably am reiterating a little bit, but with the exposure pat assessment.

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FRTR Presenter: particularly in superfund. We're looking at all these various pathways. So again, inhalation, the gases, the vapor, airborne particles, including soil. So if you're playing in the soil, and you know it can become airborne

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FRTR Presenter: ingestion. Be it the soil, the water, your food

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FRTR Presenter: and dermal contact.

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FRTR Presenter: So we're looking at site, specific exposure pathways.

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FRTR Presenter: So

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FRTR Presenter: you may be looking at oops.

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FRTR Presenter: Sorry. So they're sort of standard assumptions made. But then you also have to look at things site specifically. And then what are the current and future land use for your area?

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FRTR Presenter: And we look at the reasonable maximum exposure. So the high end exposure to the sensitive populations

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FRTR Presenter: to be protective of vulnerable groups in the community.

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FRTR Presenter: So often we're looking at children because we can. They're more sensitive than an adult, but by reasonable maximum exposure, it should be noted again, the word reasonable is important here. So if you're familiar with the there's an eating disorder known as pica. People who eat

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FRTR Presenter: There are populations, for example, of women who are known to eat clay and we don't look at those. That's not really. I mean, I guess if you had an entire population we would. But that's not really considered to be reasonable exposure.

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FRTR Presenter: Okay. And then, just to get into, give some examples to get into the specifics with superfund

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FRTR Presenter: for example, generally especially for residential, not for, like commercial. The default receptor is going to be a child because they're more sensitive than an adult.

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FRTR Presenter: So, for example, some default, exposure, assumptions are a body mass of 15 kg, exposure, duration of 6 years.

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FRTR Presenter: We assume that the person goes on vacation, in other words, away from home for 2 weeks out of the year, so they're exposed for 350 days a year. And then there are other exposure parameters, and these all come from, like most of our parameters, come from EPA's exposure factors, handbook.

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FRTR Presenter: Now, risk. So that's integrating the data from from everything you've done, from from the data gathering, from the toxicity assessments and from the exposure assessments.

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FRTR Presenter: And so

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FRTR Presenter: you, you combine them all, and you evaluate the uncertainty. And then that data, and you summarize everything to consider the overall health risk

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FRTR Presenter: in a number or estimate

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FRTR Presenter: and different methods are used for cancer versus non-cancer.

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FRTR Presenter: And again, you're considering you consider all the pathways. But maybe one is creating more of a risk than another, and which contaminants are causing these health risks.

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FRTR Presenter: So again, super fun in calculating risk for cancer, we're usually using a target risk value somewhere between 10 to the minus 6 and 10 to the minus 4 as being considered acceptable. Depending upon the situation

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FRTR Presenter: for non-cancer risk. We're using a hazard index and normally greater than one indicates a potential risk.

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FRTR Presenter: It does not mean with all these numbers, it doesn't mean there's

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FRTR Presenter: somebody's going to get a health effect. If we're just looking at

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FRTR Presenter: an acceptable or non-acceptable risk.

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FRTR Presenter: and the risk is calculated for all contaminants present and for all media they are present in

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FRTR Presenter: that's well for superfund that's related to the spill or release.

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FRTR Presenter: So for cancer risk.

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FRTR Presenter: it's the sum of the individual chemical cancer risks.

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FRTR Presenter: And again, we're looking at 10 to the minus 6 or 10 to the minus 4 for being acceptable.

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FRTR Presenter: And so just thinking about pfas at the moment, this would be, the total cancer risk would be pfoa and pfas combined, because those are the only 2 pfas that at the moment we have a cancer value for.

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FRTR Presenter: And I should also note, those are both ingestion cancer values. We don't have inhalation, toxicity for any pfas at the moment.

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FRTR Presenter: Now, a hazard index

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FRTR Presenter: is so the the hazard index is the sum of the hazard quotients.

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FRTR Presenter: Now a hazard quotient is the exposure divided by a reference dose

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FRTR Presenter: And then again, you sum those to get the hazard index.

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FRTR Presenter: now again using pfas as an example. So right now in superfund, the hazard index for a pfas would be

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FRTR Presenter: combining the hazard quotients for all the different pfas for which we have

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FRTR Presenter: a toxicity value.

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FRTR Presenter: we don't have toxicity values for a lot of pfas, but you can consider that like within your uncertainty.

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FRTR Presenter: but you can never forget that there there are other contaminants that, in fact exist besides pfas. So, in other words.

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FRTR Presenter: If you have a chrome plating site

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FRTR Presenter: and you find that there's pfas there. Well.

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FRTR Presenter: then, you probably also have chromium which you need to be considering the risk of

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FRTR Presenter: now for the Circle. Hq. I thought I'd go into a little bit more specifics here. So, for example, the

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FRTR Presenter: for the Circle, Hq for the tap water screening level. When we're computing this, this is based on both the ingestion of tap water, the inhalation of tap water. So think about like when you're in the shower. If there are volatiles in the drinking, water can become airborne, and you can be breathing that in

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FRTR Presenter: also the dermal contact with the tap water.

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FRTR Presenter: Now for pfas, specifically, none of these, again, have inhalation toxicity values.

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FRTR Presenter: So currently, that's not going to be combined in there. Now, when we do our calculations, several of the pfas do, in fact, have a dermal component, but generally it's pretty much insignificant compared to the ingestion, and the dermals based on

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FRTR Presenter: physicochemical properties.

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FRTR Presenter: And there's

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FRTR Presenter: there's guidance on how we calculate that

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FRTR Presenter: so

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FRTR Presenter: totally expecting you to memorize all these equations. I'm about to show you, but I just kind of wanted to show it to you as an example and of note. All these equations I'm about to show you can be found on our regional screening levels

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FRTR Presenter: website.

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FRTR Presenter: But this is just to show you that again, as an example with tap water.

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FRTR Presenter: it's a combination of the ingestion, the inhalation and the dermal.

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FRTR Presenter: And we do this really weird

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FRTR Presenter: inverse of the inverses. And I don't honestly remember why we do that.

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FRTR Presenter: And

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FRTR Presenter: so for the tap water screen level for ingestion.

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FRTR Presenter: Again, we're considering that reference dose, and we're looking. And then the rest of what is in here is those exposure parameters. So, in other words, your averaging time for exposure, your exposure, duration.

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FRTR Presenter: the the body mass for a child, which is 15 kg, and the child is assumed to ingest 0 point 7 8 liters of water per day.

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FRTR Presenter: This is a crazy set of equations. But again, this is how we look at the the Dermal exposure for tap water.

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FRTR Presenter: Again, you can find all these on the website. And really, if you want to get into the the.

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FRTR Presenter: the, the minutia of how we compute all this

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FRTR Presenter: and just to show you an example, for the Pfas for the Rsls. And I wanted to compare them to the Mcls.

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FRTR Presenter: You can see the reference doses that for all these pfas, and they vary quite a bit. But you'll notice only Pfo and Pfos have cancer values.

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FRTR Presenter: And so

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FRTR Presenter: with the

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FRTR Presenter: when you're looking at risk

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FRTR Presenter: because you need to combine the different Hqs

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FRTR Presenter: to get your hazard index. If so if you have a very rare site where you have one and only one contaminant there.

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FRTR Presenter: your Hq. Is equal to your HI. In other words, your hazard index is based on that one contaminant.

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FRTR Presenter: whereas if you have multiple ones, you have to combine those Hq's.

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FRTR Presenter: So for simplicity to as for ease of use with the regional screening levels.

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FRTR Presenter: We produce tables at an Hq. Of one which, again, is representative of, if you have one contaminant, we also produce tables with an Hq. Of 0 point 1 that is based on the theory of you have a site that has 10 contaminants.

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FRTR Presenter: So in other words, you'd want a 10th of your hazard quotient per contaminant. You combine them. Now you have a hazard index of one.

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FRTR Presenter: That's the theory.

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FRTR Presenter: Are the regional screening levels are just a tool. They're not guidance. They're not regulatory. They're not

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FRTR Presenter: cleanup levels.

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FRTR Presenter: But these are just tools. And these can kind of help, quick, easy use when you're investigating a site. And it can kind of show you how the screening levels you need to go lower if you have multiple contaminants.

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FRTR Presenter: And just to also kind of can show you how the screen levels are based solely on a risk calculation

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FRTR Presenter: we don't consider.

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FRTR Presenter: We only consider the toxicity and the exposure.

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FRTR Presenter: we don't consider, for example, the fact that a screen level may be below a detection limit, and there's absolutely no way to, you know. Get to that number. It's just a calculation. And so that's 1 of the reasons I wanted to compare them to the Mcl. So you can see how there is a difference between these numbers, because the Mcls are regulatory and they have to consider. You know.

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FRTR Presenter: things like, can you detect it at that level.

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FRTR Presenter: now, I kind of wagered. There'd be some people who perhaps

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FRTR Presenter: 1st heard of a hazard index

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FRTR Presenter: when EPA's office of water produced an Mcl. For pfas the pfas HI. Mcl

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FRTR Presenter: so I thought it'd be kind of a an interesting, I thought, for those who are not familiar with the hazard index. This would be a good way to kind of

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FRTR Presenter: explain a little bit more about a hazard index to compare the Circle Hazard index to the the Sidwa Hazard index. Just to kind of show you how things can change, depending upon your program, your assumptions and things like that.

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FRTR Presenter: So both of these, the the Circula and the Sidwa Hazard index. They're both based on that same overall concept of combining

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FRTR Presenter: the hazard quotients from different compounds into a total hazard index, a total risk, calculation.

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FRTR Presenter: The Cidwa excuse me, the Safe Drinking Water Act. Cigwa is based on Cidwa regulations. The Circle Hi is based on circle regulations, and it's based on our guidance.

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FRTR Presenter: Neither is wrong. They're just different.

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FRTR Presenter: So with Sibwa, their HI is based on 4 pfas, they're based on Pf, and a Pfhxs. Pfbs.

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FRTR Presenter: an Hfpo dimer, which some people call Gen. X.

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FRTR Presenter: It uses a Sidwa health based water concentration for the ratio, and these are regulatory, so they can only change with regulatory updates.

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FRTR Presenter: Now, the Cercla Hi is based on all pfas found at a site

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FRTR Presenter: plus any other contaminant non pfas contaminants found at a site

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FRTR Presenter: or at least those that which we have a toxicity value.

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FRTR Presenter: We're, however, with Cercla. We're only looking at the exposure that's related to a spill or a release.

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FRTR Presenter: and our values will be updated when we get new toxicity information. So, for example, a couple months ago, I guess now, the EPA's office of research and developed released a new iris value for Pfda.

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FRTR Presenter: So when we update the regional screen levels in a couple of weeks

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FRTR Presenter: it'll be put in there.

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FRTR Presenter: We are awaiting Iris assessments on Pf. And A and pfa checks. When we get the final value we'll be considering those

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FRTR Presenter: again. So the Circle Hi is based on what we refer to as rags

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FRTR Presenter: risk assessment, guidance for superfund.

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FRTR Presenter: I've always considered the acronym rags to be somewhat funny. But anyway, so we use those equations.

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FRTR Presenter: And for the sake of comparison, I've sort of adjusted the equation to allow easier comparison to the Sidba equations.

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FRTR Presenter: And what I'm about to present again, it ignores non pfas contaminants that may be present, and also should be used in a calculation.

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FRTR Presenter: So the circle. HI.

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FRTR Presenter: This is long again. It's the exposure dividing it by the screening level to give that ratio for your hazard. Quotient.

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FRTR Presenter: Okay, so these are the the

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FRTR Presenter: reference doses for the various pfas.

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FRTR Presenter: they all have the exact same drinking water, intake.

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FRTR Presenter: body mass

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FRTR Presenter: number

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FRTR Presenter: so you're. And then the Rsc. Is a relative source

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FRTR Presenter: contribution. Just hang on to these for a minute, because

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FRTR Presenter: once I show the Sidwell, I'll kind of explain why I'm showing them for Circle F.

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FRTR Presenter: But for Cercla the Rsc. Is always one.

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FRTR Presenter: because we are only concerned about a spill or release.

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FRTR Presenter: and then I have an asterisk by Pfo and Pfos. Just as a reminder, those have a cancer value. So while they're part of the Hi, you also have to consider the cancer value.

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FRTR Presenter: Now the Sidwa Hi is again based on only 4 pfas

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FRTR Presenter: and their health-based water concentration is the Rfd. Divided by the drinking water intake.

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FRTR Presenter: divided by the body mass and then multiplied by that relative source contribution.

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FRTR Presenter: So

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FRTR Presenter: they're using now.

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FRTR Presenter: with one exception. For so for 3 of these

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FRTR Presenter: we use the same toxicity value as offset water does for Pfh excess.

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FRTR Presenter: We're both using the Atsdr minimal risk level. But office of water has applied an extra uncertainty factor.

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FRTR Presenter: that has to do with

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FRTR Presenter: chronic versus subchronic.

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FRTR Presenter: Olem has not done that. So we we have a slightly different value because we haven't applied that value.

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FRTR Presenter: and you'll note that they use. They have different drinking water intakes and body mass numbers

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FRTR Presenter: depending upon the the different pfas.

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FRTR Presenter: I think I have a slide explaining why in here they use a relative source contribution of point 2. So what that means is

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FRTR Presenter: when it comes to. For example, pf, and A, they're saying.

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FRTR Presenter: in order to stay below a risk level, 20% of your Pf. And a daily intake can come from drinking water

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FRTR Presenter: because another 8, but because they're saying 80% can come from

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FRTR Presenter: wherever. So maybe that's

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FRTR Presenter: the carpet in, you know, in the house you live in. Maybe that is.

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FRTR Presenter: I don't know. The food you buy.

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FRTR Presenter: This is compares to Circula, where again, we're only looking at the Spiller release. So we don't consider the carpet in your house, unless the carpet is somehow or another related to the release into the environment.

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FRTR Presenter: and they use different.

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FRTR Presenter: So I've got the different Hbwcs on here.

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FRTR Presenter: I think this is slightly out of place. But this is just sort of a

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FRTR Presenter: sorry I don't. I thought I'd rearrange these a little bit. I I'd put this in here just as a note that

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FRTR Presenter: states. So if you have a site, you have to consider both Federal and may need to consider the State and the States have different. They have their own water levels, right? They use sometimes they're using different toxicity values, and they also use different exposure parameters. So in other words, the States may have different risk levels from EPA

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FRTR Presenter: They have different regulations. They have different priorities.

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FRTR Presenter: They look at things differently.

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FRTR Presenter: Is this the I'm sorry, Jean, is this, I don't think this is the updated one.

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FRTR Presenter: If you want to give me a minute. I can try. But that should have been. It might take a second. It's okay. I apologize. I had updated this just a little bit to put in a couple of explanatory things, and this doesn't appear to be it.

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FRTR Presenter: I'm gonna see? Give us 1 min to see if Gene can find it.

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FRTR Presenter: I apologize. I had when I was sending this through review, I got some good questions. And I'm like, Okay, these are good questions. And if somebody at EPA has this question, then somebody else might have a question, and so I inserted a couple of extra things into the slides.

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FRTR Presenter: And so, Linda, it might take us about a minute or 2 to pull that up, because I've got to sync over are there potentially questions in the room that we could take while we're doing that because I do have some online.

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FRTR Presenter: There aren't any in the room. I might take a question or 2 here online while I'm looking for that. And so, Linda, as I'm looking through here, there was a question that came through asking, what would a Sdwa so safe drinking Water Act versus Cercla hazard index difference, be

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FRTR Presenter: they could differ quite a bit. So, in other words, like, in other words, would the numbers come out differently?

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FRTR Presenter: if that's what the question is.

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FRTR Presenter: So

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FRTR Presenter: if you have.

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FRTR Presenter: let's see.

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FRTR Presenter: In other words, if you have a site that has

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FRTR Presenter: these 4 pfas, and only these 4 pfas

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FRTR Presenter: you actually.

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FRTR Presenter: then the Circle Hi and the Sidba Hi are actually still going to differ

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FRTR Presenter: because we use different exposure parameters.

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FRTR Presenter: and I can't tell you what the numbers would be just like off the top of my head. But, for example, if you had.

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FRTR Presenter: if you had a site with these 4 pfas, but then you also had

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FRTR Presenter: you know. Pf, HXA

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FRTR Presenter: super fun. We use a toxicity. We have an Irish toxicity value for that. So

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FRTR Presenter: so, in other words, that would go into the hi used for Circula. But it doesn't go into the hi used for Sidwa.

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FRTR Presenter: because

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FRTR Presenter: the regulation is based on these 4.

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FRTR Presenter: So it, for example, I heard somebody in here. Basically, I don't remember who it was, but somebody complaining about the how the super how the the regulations regarding pfas keep changing, and that's irritating them. And I feel your pain. I. We update the regional screening levels every 6 months, and I've heard

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FRTR Presenter: numerous people, both outside EPA and people within EPA, who complain. We update them too often. So we have to find a balance between keeping them up to date with new information. But like not changing them so often that you can't get anything done.

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FRTR Presenter: so yeah.

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FRTR Presenter: okay, I see another question that came in online. And this one is asking. They just make an observation that traditionally pfas have been considered not to be able to penetrate human skin because they're ionized. And that's why dermal risks have been considered negligible. But they quoted a study from 2024 that showed that particularly smaller pfas can seem to get through the skin barrier.

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FRTR Presenter: They were just wondering if EPA is aware or going to look into that research or research pfas, dermal exposures and then adjust the dermal absorption equations for pfas compounds to account for this.

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FRTR Presenter: That's a really good question. So we look at Dermal we consider Dermal based on some physical chemical properties.

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FRTR Presenter: and I could not tell you right off the bat which ones they are. But basically, if you. If these physical chemical properties

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FRTR Presenter: have a ratio or a product or something at this number, we consider it within. We call it the effective predictive domain. I think it's 1 and one of our many lovely acronyms.

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FRTR Presenter: So

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FRTR Presenter: which is a long way of saying that we're not.

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FRTR Presenter: We don't. We don't look at dermal exposure like, Okay, somebody came up with the new research, and it shows that things are absorbed. Dermally, we're looking at the physical chemical properties. So

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FRTR Presenter: if the the important physical chemical properties for any chemical pfas or not. If those update that can change whether or not we're considering the dermal absorption. So

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FRTR Presenter: I am not denying at all that the science is evolving on dermal exposure to pfas.

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FRTR Presenter: Right now, we don't have like specific ways of looking at it. Apart from

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FRTR Presenter: with these.

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FRTR Presenter: these equations that we use.

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FRTR Presenter: Okay? And a similar question.

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FRTR Presenter: or sorry, a related statement. Somebody chimed in and said that the Rsc is the current main difference. I think this is getting back to an earlier question that you were answering, and they noted that there might be some changes. Once the Iris Tox value is finalized.

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FRTR Presenter: I don't know if you have any thoughts on that observation. The Rsc.

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FRTR Presenter: So the Rsc. Is a relative source contribution that is based on

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FRTR Presenter: the the office of water looks at

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FRTR Presenter: like

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FRTR Presenter: what is your exposure

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FRTR Presenter: likely to be? And I'm not in that program, so I can't. I'm not an expert on it, but superfund doesn't use it at all, because again, we're looking at the spill or release. So the relative source contribution is sort of based on the idea of. There are other sources of pfas out there.

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FRTR Presenter: That should. I don't think that would change with an iris update, unless the

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FRTR Presenter: the Irish value

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FRTR Presenter: well within Irish, they might provide some information in terms of

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FRTR Presenter: how people might be exposed.

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FRTR Presenter: however, because the Sidwa Hi is based on a regulation.

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FRTR Presenter: You have to

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FRTR Presenter: update the regulation in order to update the numbers within it.

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FRTR Presenter: Okay, this is the one that we got from the email. And I believe it's the same deck. But I just wanted to put that there. And as you're clicking through that, there was another question, when will the super fund chemical data, matrix or skittable be updated with the Mcls for and get ready

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FRTR Presenter: pfoa.

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FRTR Presenter: pfas.

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FRTR Presenter: PFHX, SPFN, a. And HFPO, hyphen, DA.

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FRTR Presenter: Yeah. So skiddom, as we call it.

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FRTR Presenter: I. Oh, gosh! So

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FRTR Presenter: we the update dates for Skidm. We have a window. That is because for those of you who are not familiar with it, scidum is used specifically for scoring a site within the hazard ranking system to determine whether or not it's eligible to become a superfund site

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FRTR Presenter: because of the public comment window when we proposed an Npl site. And then, when we finalize the Npl site, we have a window within which we do not updates. Well, in other words.

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FRTR Presenter: there's a window. When we update Skiddom.

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FRTR Presenter: We don't update it during public comment periods, because that would just screw everyone up.

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FRTR Presenter: I I want to say the next update for skin will be towards the end of the year. But please don't hold me to that. It generally. This is one of those things when the contractor tells me when we can do it, but I will say we are preparing for it, and they are our contractors already working on it with the information.

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FRTR Presenter: let me see.

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FRTR Presenter: Yes.

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FRTR Presenter: okay. So I'm sorry for the sort of the little mess up I wanted to get to these. Some other things.

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FRTR Presenter: okay. So with cercla.

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FRTR Presenter: I was showing you the equations for tap water for non-cancer. So it's a similar concept for cancer.

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FRTR Presenter: similar

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FRTR Presenter: type concept for soil. You're going to have very different equations. But the concept is the same.

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FRTR Presenter: and you're always considering with the exposure pathways.

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FRTR Presenter: which exposure pathways are appropriate for media. So like with soil. If it's the top soil you can have the dermal contact. If a child is playing with it, you can have the inhalation of the aerosols from the soil, as they're sort of, you know, spread in the air.

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FRTR Presenter: Da-da-da.

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FRTR Presenter: so discuss that.

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FRTR Presenter: Oh, I knew I had this in here with Sidwell with the Hazard index. I was noting that. My.

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FRTR Presenter: well, okay, I'm sorry. You'll note that they

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FRTR Presenter: the the receptor, the the dwi body weight that varies. I had in that table, and I apologize. These are kind of out of whack now.

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FRTR Presenter: the reason that it varies is, for example for Pfhx. They're looking at a general population adult

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FRTR Presenter: for Pf. And A and Hfpo dimer. They're looking at a lactating woman for Pfbs. They're looking at a woman of childbearing age, and that's why. So, in other words, the drinking water and the body mass of that receptor can change at those different stages.

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FRTR Presenter: Whereas again, with superfund, when you're talking residential

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FRTR Presenter: generally, we're we're looking at the child.

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FRTR Presenter: we're not looking at. We we do look at adults. But the sensitive population for residential is generally going to be a child

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FRTR Presenter: for the circle of hazard index. I think I already said this, but the exposure is only related to spill or release. So that relative source contribution is only is one.

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FRTR Presenter: typically use a child.

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FRTR Presenter: And then we do. As I was saying, we update with the new toxicity information. So we will add contaminants, and we update the toxicity of existing contaminants.

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FRTR Presenter: yeah. So this is, I've already gone through about the circle. HI.

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FRTR Presenter: Just showing that it's

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FRTR Presenter: the the Hqs. For all the different pfas.

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FRTR Presenter: Sid, I think I went through these again. But this is the table where I was noting the I was discussing that Dwi bw, you can see how it changes. Again. That's because the office of water is looking at different stages.

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FRTR Presenter: in other words, a pregnant woman, a lactating woman.

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FRTR Presenter: an adult woman.

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FRTR Presenter: Okay.

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FRTR Presenter: I apologize. That was slightly chaotic. But I I had wanted to get a little bit of extra information in there, because some good questions had been raised when I sent this for review. So

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FRTR Presenter: okay, now answer more questions. If you have any. Alright, let's turn to the room. Anyone in the room have a question, because I certainly have a queue online.

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FRTR Presenter: All right. Well, then, I'm going to turn back to our virtual audience.

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FRTR Presenter: Linda, can you comment to the various Pfas compounds that have Rtds to calculate Hqs. Do they have similar effects as far as the target organs or toxic effects, so that, adding the Hqs. To calculate an Hi would make sense

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FRTR Presenter: excellent question, so

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FRTR Presenter: I don't memorize off the top of my head. The endpoints for all the different pfas, I will say almost all of them are generally associated with liver effects.

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FRTR Presenter: But so, for example, when it comes to the screening levels, because the screening levels are kind of quick, they're just sort of you keep investigating the site. So we're really not looking at endpoints. We're just kind of thinking.

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FRTR Presenter: total cancer risk.

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FRTR Presenter: total non-cancer risk. But when you go into your full risk assessment at a superfund site, you do need to consider that. So if you have one contaminant, not necessarily pfas. But if you have a contaminant, and its only endpoint is on the kidneys.

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FRTR Presenter: Then the risk for that, and then you have another contaminant whose only endpoint is

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FRTR Presenter: the lungs. Let's say

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FRTR Presenter: you're

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FRTR Presenter: generally not going to combine those

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FRTR Presenter: but

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FRTR Presenter: a little word or caution, which for if you read, for example, the toxicity assessment of basically any contaminant out there you'll have what we call the critical effect. So this is the effect that at the lowest level of exposure there can be an effect.

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FRTR Presenter: And so, in other words, if you protect a person from that critical effect, you'll protect them from the other effects.

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FRTR Presenter: So

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FRTR Presenter: if you most contaminants have more than one effect more than one endpoint. So just because the critical effect is, the kidney doesn't mean you don't consider it with something whose critical effect is the is the the lung, because it might have effects over various different organs. So you have to do. Consider whether or not it's appropriate.

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FRTR Presenter: That's why risk assessments are fun.

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FRTR Presenter: all right. Another question from online. Can you talk about the reasoning for different receptors used with the Safe Drinking Water Act? Dwibw, is it because of the assessment endpoints.

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FRTR Presenter: So I was not a part of this. And if if you want to read the you know.

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FRTR Presenter: please read the the real good work. I believe it's, you know, thousands of pages with regard. But yeah, it's normally it has to. When you're considering the the receptor it has to do

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FRTR Presenter: with the effects. So if you have a lot of pfas have developmental effects.

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FRTR Presenter: so if it's

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FRTR Presenter: in other words, if the effect is on the fetus.

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FRTR Presenter: then you're considering the pregnant woman.

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FRTR Presenter: If the effect is

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FRTR Presenter: like on a developing child, then maybe you're considering the lactating woman. And so the explanations are provided, and I apologize. I don't want to.

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FRTR Presenter: I don't have their documents memorized, so I don't want to be

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FRTR Presenter: saying more, but it it does have to do with

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FRTR Presenter: the critical effect.

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FRTR Presenter: When can that occur? And then that's why they consider who the receptor is.

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FRTR Presenter: Okay. Another question has EPA developed any written guidance on performing risk assessments for pfas that includes legacy. Contaminants

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FRTR Presenter: risk assessment, guidance for supervisors. We don't have specific guidance for pfas.

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FRTR Presenter: but

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FRTR Presenter: rags there's

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FRTR Presenter: 5 or 6 different. There's there's rags, part A, BC,

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FRTR Presenter: E.

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FRTR Presenter: There's several and they're really wonderful documents, because they're

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FRTR Presenter: in other words.

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FRTR Presenter: they're

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FRTR Presenter: They help show how to do these and you

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FRTR Presenter: with pfas? We don't need I? I have to keep telling people stop reinventing the wheel.

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FRTR Presenter: We we already know how to do risk assessment. We understand this. It's just a new contaminant we got to deal with.

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FRTR Presenter: Alright, thank you. And we've had a few people just chime in thanking you for circling back. It was not confusing for them to follow. They appreciated it and go ahead. I see a question in the room.

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FRTR Presenter: So I wanted to follow up on that specific question, and I completely agree with you. Don't reinvent the wheel. I think the question is is that it's for a lot of sites that now we are finding out, have co-mingled contaminants. Yes, and a remedy has already been made for those historical contaminants. How you redo the cumulative risk assessment

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FRTR Presenter: as part of that? Because now you're gonna have a lot of old data that was used. How do you? How would EPA recommend doing those kind of cumulative assessments without having to go back and resample for everything.

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FRTR Presenter: Okay? So we definitely don't have guidance for that.

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FRTR Presenter: But conversely.

340
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FRTR Presenter: And so I'm not trying to evade the question. But we always like, for example, when sites go into 5 year reviews

341
00:42:38,780 --> 00:42:43,339
FRTR Presenter: one of the questions with the 5 Year Review. Is, is there new science that needs to be addressed?

342
00:42:43,520 --> 00:42:44,610
FRTR Presenter: So

343
00:42:46,410 --> 00:42:47,240
FRTR Presenter: and

344
00:42:47,270 --> 00:43:06,520
FRTR Presenter: I will say, like, if you have a site, let's say you've been doing pump and treat for 30 years right? And now you discover there's pfas there. Well, maybe you know some of the original contaminants are either not there anymore, or they're at much lower concentration. So I think you're gonna have, you have to reopen the risk assessment.

345
00:43:06,650 --> 00:43:10,530
FRTR Presenter: But you're not necessarily going to be using data from 30 years ago.

346
00:43:10,560 --> 00:43:21,670
FRTR Presenter: right? Because that may not represent what's going on there. But conversely, like, aside from risk, you do need to consider the pfas from the standpoint of

347
00:43:22,640 --> 00:43:27,690
FRTR Presenter: like. If you have a site where you've been using Isco.

348
00:43:27,870 --> 00:43:31,209
FRTR Presenter: that might be like making the Pfas situation worse.

349
00:43:31,290 --> 00:43:40,560
FRTR Presenter: So you need to consider, you know. In other words, okay, how do you deal with the risk, you know? Is there versus the the risk you hadn't considered yet.

350
00:43:42,970 --> 00:43:46,889
FRTR Presenter: I know that's not an answer. But

351
00:43:47,710 --> 00:43:54,689
FRTR Presenter: I I don't see a saying use data from 30 years ago. In other words, what kind of risk is there now?

352
00:43:55,580 --> 00:43:56,660
FRTR Presenter: Does that help?

353
00:43:57,230 --> 00:44:00,909
FRTR Presenter: I see a comment here at the table. Go ahead.

354
00:44:01,700 --> 00:44:06,200
FRTR Presenter: It's a question sure. So similarly, with

355
00:44:06,690 --> 00:44:11,139
FRTR Presenter: not reinventing the wheel, but pfas being kind of a exotic

356
00:44:11,380 --> 00:44:12,700
FRTR Presenter: in some ways.

357
00:44:12,720 --> 00:44:27,009
FRTR Presenter: would EPA ever develop risk exposure, guidelines for concrete or surface water foam which we often hear about in media, but don't actually have risk assessment

358
00:44:27,800 --> 00:44:28,920
FRTR Presenter: methods

359
00:44:29,310 --> 00:44:30,949
FRTR Presenter: to do anything with.

360
00:44:38,980 --> 00:44:51,160
FRTR Presenter: so specifically with foam. I know that, like so, office of research develop office of research and development was working on like an analytical method or like how to sample foam.

361
00:44:51,530 --> 00:44:53,989
FRTR Presenter: And I remember looking at that and thinking.

362
00:44:54,210 --> 00:44:59,239
FRTR Presenter: okay, that's that's good. We're getting data. But like

363
00:44:59,840 --> 00:45:01,580
FRTR Presenter: foam is

364
00:45:02,610 --> 00:45:28,680
FRTR Presenter: like, okay, consider, we, we have I think we probably made up the word recreator. I I don't know that that's a real word, but it's a word we use. So that's to describe. Like, in other words, you have surface water, and we use the term recreator to like this is someone who's coming to swim in a creek once a week, or something like that. And that's our recreator scenario. In other words, obviously, it's extremely site, specifically.

365
00:45:29,290 --> 00:45:31,869
FRTR Presenter: But we consider, in other words.

366
00:45:32,020 --> 00:45:40,420
FRTR Presenter: the with the surface water you're considering inadvertent ingestion of the water while you're swimming, especially a child.

367
00:45:40,780 --> 00:45:48,630
FRTR Presenter: You and you do very much consider the dermal contact. So you have to look at what is the surface area of the body when you're swimming.

368
00:45:49,440 --> 00:45:51,389
FRTR Presenter: So when it comes to foam?

369
00:45:52,027 --> 00:45:55,890
FRTR Presenter: I know they've been looking at. Okay, you have this foam layer on the legs.

370
00:45:56,040 --> 00:45:57,070
FRTR Presenter: Well.

371
00:45:57,110 --> 00:45:58,150
FRTR Presenter: okay.

372
00:45:58,190 --> 00:46:01,100
FRTR Presenter: unless you have the scenario of

373
00:46:02,490 --> 00:46:03,460
FRTR Presenter: like.

374
00:46:04,135 --> 00:46:06,460
FRTR Presenter: you know, somebody sets off

375
00:46:06,530 --> 00:46:29,490
FRTR Presenter: the phone deployment system in a hangar and somebody is going around swimming through 5 feet of foam in this hangar for hours on end, which I kinda hope not. But, in other words, if if that's the case now, you're talking like body wise exposure to the foam right? Whereas if you have surface water, you're gonna have like a thin layer of foam.

376
00:46:30,890 --> 00:46:35,550
FRTR Presenter: I don't know how you work with that. And and the reason is because, in other words.

377
00:46:35,620 --> 00:46:39,119
FRTR Presenter: you are exposed to the foam, there's not a doubt about it.

378
00:46:39,410 --> 00:46:40,990
FRTR Presenter: But the foam is.

379
00:46:41,320 --> 00:46:47,139
FRTR Presenter: you know probably gonna be less than an inch in depth. So what is your

380
00:46:47,670 --> 00:46:49,260
FRTR Presenter: exposure?

381
00:46:49,590 --> 00:46:59,139
FRTR Presenter: And I don't know how to handle that. And and, in other words, because you want to consider it. But you're not swimming in foam. You're swimming in water with contact with foam.

382
00:47:01,500 --> 00:47:02,700
FRTR Presenter: So

383
00:47:03,580 --> 00:47:13,709
FRTR Presenter: that's why we say in superfund. Every side is a snowflake, and you have to figure out how you know what is your reasonable maximum exposure.

384
00:47:14,150 --> 00:47:17,759
FRTR Presenter: But what is the reasonable maximum exposure

385
00:47:17,840 --> 00:47:22,610
FRTR Presenter: which is a non answer, but that's how it needs to be considered.

386
00:47:22,950 --> 00:47:23,720
FRTR Presenter: No.

387
00:47:26,930 --> 00:47:28,250
FRTR Presenter: all right, Kent.

388
00:47:28,360 --> 00:47:58,079
FRTR Presenter: I see you checking your clock. I will just say that there's a lot of comments coming in online supporting your concepts, Linda, that we should be treating pfas like any other site related contaminant. We should be going out there and collecting new data. If it's a new thing that we need to work with, then we go get new data for what's going on right now. So I wanted to chime in and share some of what I'm seeing online. Kent, I'm looking at 1232 by my clock.

389
00:47:59,000 --> 00:48:00,880
FRTR Presenter: What time would that make it.
